Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors
APPLIED PHYSICS LETTERS, cilt.93, sa.10, 2008 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 93 Sayı: 10
- Basım Tarihi: 2008
- Doi Numarası: 10.1063/1.2980036
- Dergi Adı: APPLIED PHYSICS LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Abdullah Gül Üniversitesi Adresli: Hayır
Özet
We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/f noise by 100-fold, resulting in a deflection resolution of 0.065 angstrom in air. (c) 2008 American Institute of Physics.