Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors

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Icoz K., Iverson B. D., Savran C.

APPLIED PHYSICS LETTERS, vol.93, no.10, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 10
  • Publication Date: 2008
  • Doi Number: 10.1063/1.2980036
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Abdullah Gül University Affiliated: No


We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/f noise by 100-fold, resulting in a deflection resolution of 0.065 angstrom in air. (c) 2008 American Institute of Physics.