Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis


Ercan A. , Cui J., Hazen M. M. , Batliwalla F., Royle L., Rudd P. M. , ...Daha Fazla

ARTHRITIS RESEARCH & THERAPY, cilt.14, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 14 Konu: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/ar3756
  • Dergi Adı: ARTHRITIS RESEARCH & THERAPY

Özet

Introduction: Rheumatoid arthritis (RA) is associated with hypogalactosylation of immunoglobulin G (IgG). We examined whether a proxy measure for galactosylation of IgG N-glycans could predict response to therapy or was differentially affected by methotrexate (MTX) or TNF blockade.