Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis


Ercan A. , Cui J., Hazen M. M. , Batliwalla F., Royle L., Rudd P. M. , ...More

ARTHRITIS RESEARCH & THERAPY, vol.14, no.2, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1186/ar3756
  • Title of Journal : ARTHRITIS RESEARCH & THERAPY

Abstract

Introduction: Rheumatoid arthritis (RA) is associated with hypogalactosylation of immunoglobulin G (IgG). We examined whether a proxy measure for galactosylation of IgG N-glycans could predict response to therapy or was differentially affected by methotrexate (MTX) or TNF blockade.