Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats


Karakurt S., Semiz A., Celik G., Gencler-Ozkan A. M. , Sen A. , ADALI O.

PHARMACEUTICAL BIOLOGY, vol.51, no.5, pp.650-658, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/13880209.2012.762404
  • Title of Journal : PHARMACEUTICAL BIOLOGY
  • Page Numbers: pp.650-658

Abstract

Context: Natural products have attracted increasing interests due to their use in flavoring, nutrition, cosmetics, pharmacy and medicine. Epilobium hirsutum L. (Onagraceae) is known for its analgesic, antimicrobial, and antiproliferative activity. CYP1A1 and CYP2E1, xenobiotic metabolizing enzymes, serve as a metabolic activation route yielding reactive metabolites that are eliminated by the action of NQO1 and glutathione peroxidase (GPx) enzymes.