Synthesis and characterization of stimuli-responsive poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidone)

Dincer S., RZAEV Z., PISKIN E.

JOURNAL OF POLYMER RESEARCH, vol.13, no.2, pp.121-131, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1007/s10965-005-9014-x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.121-131
  • Abdullah Gül University Affiliated: No


Radical copolymerization of N-isopropylacrylamide (NIPA) with N-vinyl-2-pyrrolidone (VP) were carried out with 2,2'-azobisisobutyronitrile (AIBN) as an intiator in NW-dimethylformamide solution at 65 degrees C under nitrogen atmosphere. Compositon of the copolymers synthesized in a wide range of monomer feed ratios were determined by FTIR and H-1 (C-13) NMR-DEPT-135 spectroscopy. The monomer reactivity ratios were determined by Fineman-Ross, Kelen-Tudos and non-linear regression methods. It was observed that the studied monomer pair has some tendency to alternation in the chosen monomer feed ratios due to fort-nation of intermolecular interaction through H-bonding and N -> 0 = C coordination. The synthesized poly(NIPA-co-VP)s show temperature sensitivity (T-s), higher glass-transiton temperature (T-g), thermal stability, polyelectrolyte and stimuli-responsive (temperature- and pH-sensitive) behavior and can be attributed to the class of bioengineering functional copolymers useful for application in various gene- and bioengineering processes, drug delivery systems and biomacromolecule conjugations.