A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells

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Gokbulut A., Yasar M., Baran Y.

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.2, pp.118-126, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2013.0381
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.118-126
  • Keywords: Apoptosis, Cell cycle arrest, Chronic lymphocytic leukemia, KL-21, QUERCETIN-INDUCED APOPTOSIS, TARAXACUM-OFFICINALE, SOLIDAGO-VIRGAUREA, SILYBUM-MARIANUM, PROSTATE-CANCER, ESSENTIAL OIL, DOUBLE-BLIND, L. EXTRACT, ANTIOXIDANT, TRANSPLANTATION
  • Abdullah Gül University Affiliated: Yes

Abstract

Objective: The aims of this study were to examine the cytotoxic and apoptotic effects of KL-21, a novel plant product (produced by Naturin Natural Products, Izmir, Turkey), on 232B4 chronic lymphocytic leukemia (CLL) cells and to determine the cytotoxic effects on healthy BEAS-2B human bronchial epithelial cells.