Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating

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Caglayan H., Cakmakyapan S., Addae S. A., Pinard M. A., Caliskan D., Aslan K., ...More

APPLIED PHYSICS LETTERS, vol.97, no.9, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 97 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.1063/1.3484958
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Abdullah Gül University Affiliated: No


In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures. (C) 2010 American Institute of Physics. [doi:10.1063/1.3484958]