Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating

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Caglayan H., Cakmakyapan S., Addae S. A., Pinard M. A., Caliskan D., Aslan K., ...More

APPLIED PHYSICS LETTERS, vol.97, no.9, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 97 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.1063/1.3484958
  • Journal Name: APPLIED PHYSICS LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Abdullah Gül University Affiliated: No

Abstract

In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures. (C) 2010 American Institute of Physics. [doi:10.1063/1.3484958]