Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating


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Caglayan H., Cakmakyapan S., Addae S. A., Pinard M. A., Caliskan D., Aslan K., ...Daha Fazla

APPLIED PHYSICS LETTERS, cilt.97, sa.9, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1063/1.3484958
  • Dergi Adı: APPLIED PHYSICS LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Abdullah Gül Üniversitesi Adresli: Hayır

Özet

In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures. (C) 2010 American Institute of Physics. [doi:10.1063/1.3484958]