Nilotinib Does Not Alter the Secretory Functions of Carotid Artery Endothelial Cells in a Prothrombotic or Antithrombotic Fashion

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Katgi A., Sevindik O. G., Adan A., Ozsan G. H., Yuksel F., Solmaz S. M., ...More

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.21, no.7, pp.678-683, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.1177/1076029614550817
  • Journal Name: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.678-683
  • Keywords: nilotinib, endothelial cells, carotid artery, function, cell viability, CHRONIC MYELOID-LEUKEMIA, DISEASE, THERAPY, IMATINIB, EVENTS
  • Abdullah Gül University Affiliated: Yes

Abstract

Background: There have been concerns about the possible prothrombotic effects of nilotinib, especially in patients having cardiovascular risk factors. The potential mechanism behind the increased risk of thromboembolic events is still not clear.