Modulatory actions of o-coumaric acid on carcinogen-activating cytochrome P450 isozymes and the potential for drug interactions in human hepatocarcinoma cells


Sen A. , Terzioglu G., Atmaca P., Celik G., Ozgun O., Arslan S.

PHARMACEUTICAL BIOLOGY, vol.53, no.9, pp.1391-1398, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.3109/13880209.2015.1014919
  • Title of Journal : PHARMACEUTICAL BIOLOGY
  • Page Numbers: pp.1391-1398
  • Keywords: Carcinogen activation, cytochrome P450 (CYP), HepG2 cells, PHENOLIC-ACIDS, N-NITROSODIMETHYLAMINE, METABOLIZING-ENZYMES, CHLOROGENIC ACIDS, CIGARETTE-SMOKE, PLANT PHENOLICS, MESSENGER-RNA, HEPATOMA-CELL, EXPRESSION, INDUCTION

Abstract

Context: Although humans are exposed to o-coumaric acid (OCA) in their diet, there is no available literature related to drug interaction and the carcinogen-activating potential of OCA in the HepG2 cell line.