Modulatory actions of o-coumaric acid on carcinogen-activating cytochrome P450 isozymes and the potential for drug interactions in human hepatocarcinoma cells

Sen A., Terzioglu G., Atmaca P., Celik G., Ozgun O., Arslan S.

PHARMACEUTICAL BIOLOGY, vol.53, no.9, pp.1391-1398, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.3109/13880209.2015.1014919
  • Journal Name: PHARMACEUTICAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1391-1398
  • Keywords: Carcinogen activation, cytochrome P450 (CYP), HepG2 cells, PHENOLIC-ACIDS, N-NITROSODIMETHYLAMINE, METABOLIZING-ENZYMES, CHLOROGENIC ACIDS, CIGARETTE-SMOKE, PLANT PHENOLICS, MESSENGER-RNA, HEPATOMA-CELL, EXPRESSION, INDUCTION
  • Abdullah Gül University Affiliated: No

Abstract

Context: Although humans are exposed to o-coumaric acid (OCA) in their diet, there is no available literature related to drug interaction and the carcinogen-activating potential of OCA in the HepG2 cell line.