Modulatory actions of o-coumaric acid on carcinogen-activating cytochrome P450 isozymes and the potential for drug interactions in human hepatocarcinoma cells

Sen A., Terzioglu G., Atmaca P., Celik G., Ozgun O., Arslan S.

PHARMACEUTICAL BIOLOGY, cilt.53, sa.9, ss.1391-1398, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/13880209.2015.1014919
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1391-1398
  • Anahtar Kelimeler: Carcinogen activation, cytochrome P450 (CYP), HepG2 cells, PHENOLIC-ACIDS, N-NITROSODIMETHYLAMINE, METABOLIZING-ENZYMES, CHLOROGENIC ACIDS, CIGARETTE-SMOKE, PLANT PHENOLICS, MESSENGER-RNA, HEPATOMA-CELL, EXPRESSION, INDUCTION
  • Abdullah Gül Üniversitesi Adresli: Hayır

Özet

Context: Although humans are exposed to o-coumaric acid (OCA) in their diet, there is no available literature related to drug interaction and the carcinogen-activating potential of OCA in the HepG2 cell line.