Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition

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Baran Y., Zencir S., Cakir Z., ÖZTÜRK E., TOPÇU Z.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol.36, no.6, pp.673-679, 2011 (SCI-Expanded) identifier identifier


What is known and Objective: Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that generates the BCR/ABL fusion protein. Recent studies showed that the imatinib has cytotoxic and apoptotic effects on many BCR/ABL-negative cancers. Numerous compounds with cytotoxic potential exert their functions by interfering with the DNA topoisomerase. In this study, we examined the effects of imatinib on tumour cell-killing in relation to DNA topoisomerase enzyme inhibition.