The effects of the initial texture, velocity gradient, strain increment and type of interaction tensor on the strain hardening response of Hadfield steel were investigated. To observe their influences on mechanical response, crystal plasticity computations were carried out with the aid of the Visco-Plastic Self-Consistent (VPSC) algorithm. Specifically, uniaxial deformation response of Hadfield steel was modeled based on the experimental deformation response at a strain rate of 1x10(-1) s(-1) and corresponding Voce hardening parameters were calculated. The same Voce hardening parameters were utilized with different boundary conditions in the VPSC simulations to identify the roles of the aforementioned microstructural properties. The current results demonstrate the importance of these microstructural properties for reliable predictions of the strain hardening response of Hadfield steel and constitute an important guideline for the proper selection of them.