The impact of antibody selection on the detection of cardiac troponin I


Guy M. J. , Chen Y., Clinton L., Zhang H., Zhang J., Dong X., ...More

CLINICA CHIMICA ACTA, vol.420, pp.82-88, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 420
  • Publication Date: 2013
  • Doi Number: 10.1016/j.cca.2012.10.034
  • Title of Journal : CLINICA CHIMICA ACTA
  • Page Numbers: pp.82-88

Abstract

Background: Cardiac troponin I (cTnI) is the current standard biomarker for diagnosing acute myocardial infarction and for risk-stratification of acute coronary syndromes in patients. However, it remains unclear how the epitope specificity of antibodies in immunoassays influences the detection of various modified forms of cTnI.