The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinib-resistant chronic myeloid leukemia cells

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Bozkurt S., Ozkan T., ÖZMEN F., Baran Y., Sunguroglu A., Kansu E.

HEMATOLOGY, vol.18, no.4, pp.217-223, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.1179/1607845412y.0000000056
  • Journal Name: HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.217-223
  • Abdullah Gül University Affiliated: No

Abstract

In chronic myeloid leukemia (CML), epigenetic modifications such as promoter hypermethylation and inactive histone modification are known mechanisms of drug resistance. In our study, we investigated the roles of promoter hypermethylation of BIM and BID genes and H3K27me3 histone modification on imatinib resistance.