Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients


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Abaan O. D. , Mutlu P. K. , Baran Y., Atalay C., GÜNDÜZ U.

CANCER INVESTIGATION, vol.27, no.2, pp.201-205, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1080/07357900802173562
  • Title of Journal : CANCER INVESTIGATION
  • Page Numbers: pp.201-205

Abstract

Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.