Endocytosis Genes Facilitate Protein and Membrane Transport in C. elegans Sensory Cilia

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KAPLAN O. İ., Doroquez D. B., ÇEVİK KAPLAN S., Bowie R. V., Clarke L., Sanders A. A. W. M., ...More

CURRENT BIOLOGY, vol.22, no.6, pp.451-460, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1016/j.cub.2012.01.060
  • Journal Name: CURRENT BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.451-460
  • Abdullah Gül University Affiliated: Yes

Abstract

Background: Multiple intracellular transport pathways drive the formation, maintenance, and function of cilia, a compartmentalized organelle associated with motility, chemo-/mechano-/photosensation, and developmental signaling. These pathways include cilium-based intraflagellar transport (IFT) and poorly understood membrane trafficking events. Defects in ciliary transport contribute to the etiology of human ciliary disease such as Bardet-Biedl syndrome (BBS). In this study, we employ the genetically tractable nematode Caenorhabditis elegans to investigate whether endocytosis genes function in cilium formation and/or the transport of ciliary membrane or ciliary proteins.