Effective Neural Photostimulation Using Indium-Based Type-II Quantum Dots

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Jalali H. B., Aria M. M., Dikbas U. M., Sadeghi S., Kumar B. G., ŞAHİN M., ...Daha Fazla

ACS NANO, cilt.12, sa.8, ss.8104-8114, 2018 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1021/acsnano.8b02976
  • Dergi Adı: ACS NANO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8104-8114
  • Anahtar Kelimeler: quantum dot, indium phosphide, zinc oxide, type-II core/shell, neural, photostimulation, biocompatible, LIGHT-EMITTING-DIODES, VIVO TOXICITY ASSESSMENT, RETINAL GANGLION-CELLS, IN-VIVO, ENERGY-TRANSFER, SEMICONDUCTOR NANOCRYSTALS, ZNO NANOCRYSTALS, SOLAR-CELLS, REBOUND EXCITATION, INP/ZNS
  • Abdullah Gül Üniversitesi Adresli: Evet

Özet

Light-induced stimulation of neurons via photoactive surfaces offers rich opportunities for the development of therapeutic methods and high-resolution retinal prosthetic devices. Quantum dots serve as an attractive building block for such surfaces, as they can be easily functionalized to match the biocompatibility and charge transport requirements of cell stimulation. Although indium based colloidal quantum dots with type-I band alignment have attracted significant attention as a nontoxic alternative to cadmium-based ones, little attention has been paid to their photovoltaic potential as type-II heterostructures. Herein, we demonstrate type-II indium phosphide/zinc oxide core/shell quantum dots that are incorporated into a photoelectrode structure for neural photostimulation. This induces a hyperpolarizing bioelectrical current that triggers the firing of a single neural cell at 4 mu W mm(-2), 26-fold lower than the ocular safety limit for continuous exposure to visible light. These findings show that nanomaterials can induce a biocompatible and effective biological junction and can introduce a route in the use of quantum dots in photoelectrode architectures for artificial retinal prostheses.