STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells

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Kiper H. D., Kaymaz B. T., Gokbulut A., Selvi N., Avci C. B., KOSOVA B., ...Daha Fazla

BIOMEDICINE & PHARMACOTHERAPY, cilt.67, sa.6, ss.527-532, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.biopha.2013.04.006
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.527-532
  • Anahtar Kelimeler: Chronic myeloid leukemia, Zoledronic acid, STATs, ANTITUMOR-ACTIVITY, BREAST-CANCER, 3RD-GENERATION BISPHOSPHONATE, CONSTITUTIVE ACTIVATION, SIGNAL TRANSDUCER, CHRONIC-PHASE, RESISTANCE, INHIBITOR, PAMIDRONATE, INTERFERON
  • Abdullah Gül Üniversitesi Adresli: Hayır

Özet

In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies. (C) 2013 Elsevier Masson SAS. All rights reserved.