Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption

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Sen A. , Ayar B., Yilmaz A., Acar O. O. , Turgut G. C. , TOPÇU G.

TURKISH JOURNAL OF CHEMISTRY, vol.43, no.5, pp.1350-1372, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.3906/kim-1904-57
  • Page Numbers: pp.1350-1372
  • Keywords: Alysine A, alysine B, antidiabetic, Teucrium alyssifolium, glucose homeostasis, NEOCLERODANE DITERPENOIDS, BARDOXOLONE METHYL, GENE-EXPRESSION, KIDNEY-FUNCTION, INSULIN, DERIVATIVES, ACID, L.


Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses: