Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption

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Sen A., Ayar B., Yilmaz A., Acar O. O., Turgut G. C., TOPÇU G.

TURKISH JOURNAL OF CHEMISTRY, cilt.43, sa.5, ss.1350-1372, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3906/kim-1904-57
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1350-1372
  • Anahtar Kelimeler: Alysine A, alysine B, antidiabetic, Teucrium alyssifolium, glucose homeostasis, NEOCLERODANE DITERPENOIDS, BARDOXOLONE METHYL, GENE-EXPRESSION, KIDNEY-FUNCTION, INSULIN, DERIVATIVES, ACID, L.
  • Abdullah Gül Üniversitesi Adresli: Hayır

Özet

Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses: