Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption
TURKISH JOURNAL OF CHEMISTRY, cilt.43, sa.5, ss.1350-1372, 2019 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 5
- Basım Tarihi: 2019
- Doi Numarası: 10.3906/kim-1904-57
- Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1350-1372
- Anahtar Kelimeler: Alysine A, alysine B, antidiabetic, Teucrium alyssifolium, glucose homeostasis, NEOCLERODANE DITERPENOIDS, BARDOXOLONE METHYL, GENE-EXPRESSION, KIDNEY-FUNCTION, INSULIN, DERIVATIVES, ACID, L.
- Abdullah Gül Üniversitesi Adresli: Hayır
Özet
Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses: