Caffeic acid phenethyl ester triggers apoptosis through induction of loss of mitochondrial membrane potential in CCRF-CEM cells

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Avci C. B., GÜNDÜZ C., Baran Y., ŞAHİN F., Yilmaz S., Dogan Z. O., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.137, no.1, pp.41-47, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1007/s00432-010-0857-0
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.41-47
  • Abdullah Gül University Affiliated: No

Abstract

CAPE (caffeic acid phenethyl ester) is one of the most valuable and investigated component of propolis which is composed by honeybees. In the current study, we aimed at examining apoptotic effects of CAPE on CCRF-CEM leukemic cells and at determining the roles of mitochondrial membrane potential (MMP) in cell death.