Rational design of EDTA-incorporated nanoflowers as novel and effective endodontic disinfection against biofilms

ASLAN T., DADI Ş., Kafdag O., Temur N., Ildiz N., ÖÇSOY İ., ...More

Odontology, vol.112, no.2, pp.444-452, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 112 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.1007/s10266-023-00857-2
  • Journal Name: Odontology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Page Numbers: pp.444-452
  • Keywords: Biofilms, Catalytic activity, EDTA nanoflowers, Endodontic disinfection
  • Abdullah Gül University Affiliated: Yes

Abstract

The ethylenediaminetetradiacetic acid (EDTA) is one of the most commonly used irrigation solutions. Although EDTA has a very low antimicrobial property, it is used to remove inorganic part of smear layer in areas of root canal system. Herein, we developed EDTA-incorporated nanoflowers (EDTA NFs), for the first time, as novel and effective irrigation solution with quite high antimicrobial property to provide complete disinfection in root canal system. We both systematically elucidated the formation of the EDTA NFs with various techniques, and their catalytic and antimicrobial activities in the presence of hydrogen peroxide (H2O2) were documented through intrinsic EDTA property and peroxidase-like activities.