Micro- and nanodevices integrated with biomolecular probes

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Alapan Y., İÇÖZ K., Gurkan U. A.

BIOTECHNOLOGY ADVANCES, vol.33, no.8, pp.1727-1743, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 33 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1016/j.biotechadv.2015.09.001
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1727-1743
  • Keywords: Biosensing, Micro/nanofabricalion, Microcantilevers, Micro/nanopillars, Microfluidic channels, Surface functionalization, Cell adhesion, Biomolecules, Cell isolation, Point-of-care diagnosis, CIRCULATING TUMOR-CELLS, SURFACE-PLASMON RESONANCE, SICKLE-CELL, ADHESION MOLECULES, TRACTION FORCES, CANCER-CELLS, WHOLE-BLOOD, MICROFLUIDIC DEVICE, TELOMERASE ACTIVITY, EFFICIENT ISOLATION
  • Abdullah Gül University Affiliated: Yes


Understanding how biomolecules, proteins and cells interact with their surroundings and other biological entities has become the fundamental design criterion for most biomedical micro- and nanodevices. Advances in biology, medicine, and nanofabrication technologies complement each other and allow us to engineer new tools based on biomolecules utilized as probes. Engineered micro/nanosystems and biomolecules in nature have remarkably robust compatibility in terms of function, size, and physical properties. This article presents the state of the art in micro- and nanoscale devices designed and fabricated with biomolecular probes as their vital constituents. General design and fabrication concepts are presented and three major platform technologies are highlighted: microcantilevers, micro/nanopillars, and microfluidics. Overview of each technology, typical fabrication details, and application areas are presented by emphasizing significant achievements, current challenges, and future opportunities. (C) 2015 Elsevier Inc. All rights reserved.