Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells

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Cincin Z. B. , Unlu M. , Kiran B., Bireller E. S. , Baran Y., Cakmakoglu B.

CELLULAR ONCOLOGY, cilt.38, ss.195-204, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 38 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s13402-015-0222-z
  • Sayfa Sayısı: ss.195-204


Hesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer cell types. The mechanisms underlying hesperidin-induced growth arrest and apoptosis are, however, not well understood. Here, we aimed to investigate the anti-proliferative and apoptotic effects of hesperidin on non-small cell lung cancer (NSCLC) cells and to investigate the mechanisms involved.