A coefficient ratio-based sliding surface algorithm and an integral sliding mode control approach are proposed for multivariable dynamical systems. The sliding surface design problem is reduced to the specification of the desired time constant of closed-loop systems. The proposed scheme is able to accomplish a non-overshoot transient response and a short settling time for multivariable systems. The resulting sliding surfaces are robust and optimal in the existence of parameter perturbations. An integral sliding mode control approach is also developed for robust tracking by using the coefficient ratio-based robust sliding surface designs. The developed methods are implemented on a flexible robotic manipulator and a strike aircraft system, and the numerical simulation results are provided in order to show the validity and feasibility of the methods.