Synthesis of novel acridine-sulfonamide hybrid compounds as acetylcholinesterase inhibitor for the treatment of alzheimer's disease

Ulus R., Esirden I., Aday B., Turgut G. C., Sen A., Kaya M.

MEDICINAL CHEMISTRY RESEARCH, cilt.27, sa.2, ss.634-641, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00044-017-2088-2
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.634-641
  • Anahtar Kelimeler: Anticholinesterase activity, Tacrine, Acridine, Sulfonamide, CARBONIC-ANHYDRASE INHIBITORS, CYTOSOLIC ISOZYMES I, ONE-POT SYNTHESIS, MICROWAVE IRRADIATION, HIGHLY EFFICIENT, DERIVATIVES, SERIES, XII, CATALYST, AGENTS
  • Abdullah Gül Üniversitesi Adresli: Hayır

Özet

In this study we report that amino acridine intermediates 7 and 8 were obtained from the reduction of nitro acridine derivatives 5 and 6 that were synthesized via the condensation of dimedone, p-nitrobenzaldehyde with various amine derivatives, respectively. Then acridine sulfonamide hybrid compounds (9-18) were synthesized by the reaction of amino acridine 7, 8 with sulfonyl chlorides. The new hybrid compounds were characterized by FT-IR, H-1-NMR, C-13-NMR, and HRMS analyzes. The evaluation of in vitro anticholinesterase action of the synthesized compounds against AChE showed that some of them are potent inhibitors. Among them, compound 17 showed the most potent activity against AChE with an IC50 of 0.14 A mu M.