MASH Suite: A User-Friendly and Versatile Software Interface for High-Resolution Mass Spectrometry Data Interpretation and Visualization

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Guner H., Close P. L., CAİ W., ZHANG H., PENG Y., GREGORİCH Z. R., ...More

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol.25, no.3, pp.464-470, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1007/s13361-013-0789-4
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.464-470
  • Keywords: Top-down mass spectrometry, Tandem mass spectrometry, Electron capture dissociation, Data processing, Bioinformatics, CARDIAC TROPONIN-I, HEART-FAILURE, SPECTRA, PHOSPHORYLATION, PROTEOMICS, DECONVOLUTION, REDUCTION, ALGORITHM, PROTEINS, STATE
  • Abdullah Gül University Affiliated: No


The rapid advancements in mass spectrometry (MS) instrumentation, particularly in Fourier transform (FT) MS, have made the acquisition of high-resolution and high-accuracy mass measurements routine. However, the software tools for the interpretation of high-resolution MS data are underdeveloped. Although several algorithms for the automatic processing of high-resolution MS data are available, there is still an urgent need for a user-friendly interface with functions that allow users to visualize and validate the computational output. Therefore, we have developed MASH Suite, a user-friendly and versatile software interface for processing high-resolution MS data. MASH Suite contains a wide range of features that allow users to easily navigate through data analysis, visualize complex high-resolution MS data, and manually validate automatically processed results. Furthermore, it provides easy, fast, and reliable interpretation of top-down, middle-down, and bottom-up MS data. MASH Suite is convenient, easily operated, and freely available. It can greatly facilitate the comprehensive interpretation and validation of high-resolution MS data with high accuracy and reliability.