Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells

KARABULUT, BÜLENT; Erten, C.; Gul, M.; Cengiz, E.; KARACA, BETÜL; Kucukzeybek, Y.; Gorumlu, G.; Atmaca, H.; Uzunoglu, S.; ŞANLI, ULUS; Baran, Y.; Uslu, R.

doi:10.1016/j.cellbi.2008.11.011

Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells

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KARABULUT B., Erten C., Gul M. K., Cengiz E., KARACA B., Kucukzeybek Y., ...More

CELL BIOLOGY INTERNATIONAL, vol.33, no.2, pp.239-246, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 33 Issue: 2
Publication Date: 2009
Doi Number: 10.1016/j.cellbi.2008.11.011
Journal Name: CELL BIOLOGY INTERNATIONAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.239-246
Abdullah Gül University Affiliated: No

Abstract

Docetaxel, a semi-synthetic taxane analogue, is used effectively in the treatment of metastatic prostate cancer. Zoledronic acid, the most potent member of bisphosphonates, has shown pleiotropic anti-tumoral effects on prostate cancer cells. We have explored the possible additive/synergistic effects and the apoptotic pathways induced by combination treatment of docetaxel and zoledronic acid in hormone and drug refractory, PC-3 and DU-145 prostate cancer cells. Combination of docetaxel and zoledronic acid synergistically inhibits cell growth in PC-3 and DU-145 cells. Moreover, this effect was due to downregulation of antiapoptotic protein Bcl-2 in PC-3 and DU-145 cells. In conclusion, docetaxel/zoledronic acid combination is potentially a novel and effective approach for the treatment of prostate cancer. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.