Antiproliferative activity of (R)-4′-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition


Delman M., Avcı S. T. , Akçok İ. , Kanbur T., Erdal E., Çağır A.

European Journal of Medicinal Chemistry, vol.180, pp.224-237, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 180
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ejmech.2019.07.024
  • Title of Journal : European Journal of Medicinal Chemistry
  • Page Numbers: pp.224-237
  • Keywords: Hepatocellular carcinoma, Cancer stem cell, SIRT1 inhibitor, CRM1 inhibitor, Topoisomerase I inhibitor, Klavuzon, IN-VITRO, NUCLEAR TRANSPORT, DRUG-RESISTANCE, GONIOTHALAMIN, P53, APOPTOSIS, ANTICANCER, ACTIVATION, MECHANISM, EXPRESSION