Remarkable enhancement of the hydrolyses of phosphoesters by dinuclear centers: Streptomyces aminopeptidase as a 'natural model system'


Ercan A. , PARK H. I. , MİNG L. J.

CHEMICAL COMMUNICATIONS, ss.2501-2502, 2000 (SCI İndekslerine Giren Dergi) identifier identifier

  • Basım Tarihi: 2000
  • Doi Numarası: 10.1039/b004544f
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Sayfa Sayıları: ss.2501-2502

Özet

The transition-state analogues bis(p-nitrophenyl)phosphate and p-nitrophenyl phenylphosphonate for peptide hydrolysis are shown to be very effectively hydrolyzed by Streptomyces dinuclear aminopeptidase and its Co2+, Ni2+, Mn2+ and Cd2+ derivatives with high catalytic proficiencies and specific activities comparable to those of some phosphoesterases.