Remarkable enhancement of the hydrolyses of phosphoesters by dinuclear centers: Streptomyces aminopeptidase as a 'natural model system'

Ercan A., PARK H. I., MİNG L. J.

CHEMICAL COMMUNICATIONS, no.24, pp.2501-2502, 2000 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2000
  • Doi Number: 10.1039/b004544f
  • Journal Name: CHEMICAL COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2501-2502
  • Abdullah Gül University Affiliated: No

Abstract

The transition-state analogues bis(p-nitrophenyl)phosphate and p-nitrophenyl phenylphosphonate for peptide hydrolysis are shown to be very effectively hydrolyzed by Streptomyces dinuclear aminopeptidase and its Co2+, Ni2+, Mn2+ and Cd2+ derivatives with high catalytic proficiencies and specific activities comparable to those of some phosphoesterases.