Akademik Veri Yönetim Sistemi
17th Nanoscience and Nanotechnology Conference (NANOTR-17), İzmir, Türkiye, 27 - 29 Ağustos 2023, ss.32
One of the main challenges in wound care and treatment is limited antibacterial properties of wound dressing materials (Sardareh et al., 2022). The traditional applications have been unable to sufficiently meet the needs of the patients suffering from the wounds. Several methods have been utilized to design wound healing products. However, among them, the electrospinning technique has attracted more attention . This technique is a simple and convenient, allowing the production of advanced electrospun membranes with a specific structure and properties that mimic the extracellular matrix (ECM) (Liu et al., 2021). Electrospun nanofibrous membranes, with their high surface area, are excellent candidates as therapeutic agent carriers to solve problems related to infection and promote wound healing (Suganya et al., 2011). Nowadays, several herbs and their active constituents have been studied as therapeutic agents due to their significant potential for the management and treatment of wounds through multiple interconnected mechanisms. Moreover, they are affordable and generally cause minimal side effects (Maver et al., 2015). Cinnamomum zeylanicum, known for its excellent antibacterial, antifungal, and anti-inflammatory activities, has been studied extensively (Bandara et al., 2012). In our study, we employed the electrospinning technique to fabricate a novel anti-microbial nanofibrous membrane inspired by the nature of Cinnamomum zeylanicum. We fabricated nanofibrous membranes using a blend of poly(lactic acid) (PLA) and natural gelatin, along with different ratios of ethanolic extract of Cinnamomum zeylanicum, as wound dressing material. The properties of the electrospun membrane were characterized utilizing ATR-FTIR, scanning electron microscopy (SEM), and water contact angle measurements. Additionally, we conducted cell viability, swelling, biodegradation, release study, and mechanical tests to evaluate the potential of the membranes for wound healing applications. The results showed that the anti-microbial nanofibrous membrane developed in this study is a promising wound dressing candidate to effectively prevent infection in the wound area.