miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells


Firatligil B. , Avci C. B. , Baran Y.

JOURNAL OF BUON, cilt.18, ss.437-441, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 18 Konu: 2
  • Basım Tarihi: 2013
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.437-441

Özet

Purpose: In this study we examined the expression levels of miR-17 which possesses oncogenic activities through downregulation of CDKN1A, p21 and E2F1 tumor suppressor genes, in imatinib sensitive and resistant chronic myeloid leukemia (CML) cells. On the other hand, we also determined the expression levels of miR-17 in response to tyrosine kinase inhibitors imatinib, nilotinib and dasatinib used for the treatment of CML.