Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance

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Baran Y. , Guer B., Kaya P., Ural A. U. , AVCU F., Guenduez U.

HEMATOLOGY, cilt.12, ss.511-517, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 12 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/10245330701562535
  • Dergi Adı: HEMATOLOGY
  • Sayfa Sayısı: ss.511-517


The major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined.