WORLD JOURNAL OF CLINICAL CASES, vol.8, no.10, pp.1767-1792, 2020 (SCI-Expanded)
Article / Review
WORLD JOURNAL OF CLINICAL CASES
Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
Oleanolic acid, Prophylactic, Anti-inflammatory, Anti-diabetics, Neuroprotective, Hepatoprotective, NF-KAPPA-B, ALLERGIC ENCEPHALOMYELITIS MODEL, COLORECTAL-CANCER ANGIOGENESIS, IN-VITRO, BARDOXOLONE METHYL, MULTIPLE-SCLEROSIS, URSOLIC ACID, BIOLOGICAL EVALUATION, OXIDATIVE STRESS, LIVER-INJURY
Abdullah Gül University Affiliated:
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles in various diseases such as ulcerative colitis, multiple sclerosis, metabolic disorders, diabetes, hepatitis and different cancers. This review assembles and presents the latestin vivoreports on the impacts of OA and OA derivatives from various plant sources and the biological mechanisms of OA activities. Thus, this review presents sufficient data proposing that OA and its derivatives are potential alternative and complementary therapies for the treatment and management of several diseases.