Multiple Juvenile Idiopathic Arthritis Subtypes Demonstrate Proinflammatory IgG Glycosylation


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Ercan A. , Barnes M. G. , Hazen M., Tory H., Henderson L., Dedeoglu F., ...More

ARTHRITIS AND RHEUMATISM, vol.64, no.9, pp.3025-3033, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1002/art.34507
  • Title of Journal : ARTHRITIS AND RHEUMATISM
  • Page Numbers: pp.3025-3033

Abstract

Objective. Rheumatoid arthritis is associated with an excess of agalactosylated (G0) IgG that is considered relatively proinflammatory. Assessment of this association in juvenile idiopathic arthritis (JIA) is complicated by age-dependent IgG glycan variation. The aim of this study was to conduct the first large-scale survey of IgG glycans in healthy children and patients with JIA, with a focus on early childhood, the time of peak JIA incidence.