Multiple Juvenile Idiopathic Arthritis Subtypes Demonstrate Proinflammatory IgG Glycosylation

Ercan, ALTAN; Barnes, Michael; Hazen, Melissa; Tory, Heather; Henderson, Lauren; Dedeoglu, Fatma; Fuhlbrigge, Robert; Grom, Alexei; Holm, Ingrid; Kellogg, Mark; Kim, Susan; Adamczyk, Barbara; Rudd, Pauline; Son, Mary; Sundel, Robert; Foell, Dirk; Glass, David; Thompson, Susan; Nigrovic, Peter

doi:10.1002/art.34507

Multiple Juvenile Idiopathic Arthritis Subtypes Demonstrate Proinflammatory IgG Glycosylation

Ercan A., Barnes M. G., Hazen M., Tory H., Henderson L., Dedeoglu F., ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.64, sa.9, ss.3025-3033, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 64 Sayı: 9
Basım Tarihi: 2012
Doi Numarası: 10.1002/art.34507
Dergi Adı: ARTHRITIS AND RHEUMATISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.3025-3033
Abdullah Gül Üniversitesi Adresli: Hayır

Özet

Objective. Rheumatoid arthritis is associated with an excess of agalactosylated (G0) IgG that is considered relatively proinflammatory. Assessment of this association in juvenile idiopathic arthritis (JIA) is complicated by age-dependent IgG glycan variation. The aim of this study was to conduct the first large-scale survey of IgG glycans in healthy children and patients with JIA, with a focus on early childhood, the time of peak JIA incidence.