Multiple Juvenile Idiopathic Arthritis Subtypes Demonstrate Proinflammatory IgG Glycosylation


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Ercan A. , Barnes M. G. , Hazen M., Tory H., Henderson L., Dedeoglu F., et al.

ARTHRITIS AND RHEUMATISM, cilt.64, ss.3025-3033, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 64 Konu: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1002/art.34507
  • Dergi Adı: ARTHRITIS AND RHEUMATISM
  • Sayfa Sayısı: ss.3025-3033

Özet

Objective. Rheumatoid arthritis is associated with an excess of agalactosylated (G0) IgG that is considered relatively proinflammatory. Assessment of this association in juvenile idiopathic arthritis (JIA) is complicated by age-dependent IgG glycan variation. The aim of this study was to conduct the first large-scale survey of IgG glycans in healthy children and patients with JIA, with a focus on early childhood, the time of peak JIA incidence.