Multiple Juvenile Idiopathic Arthritis Subtypes Demonstrate Proinflammatory IgG Glycosylation

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Ercan A., Barnes M. G., Hazen M., Tory H., Henderson L., Dedeoglu F., ...More

ARTHRITIS AND RHEUMATISM, vol.64, no.9, pp.3025-3033, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1002/art.34507
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3025-3033
  • Abdullah Gül University Affiliated: No


Objective. Rheumatoid arthritis is associated with an excess of agalactosylated (G0) IgG that is considered relatively proinflammatory. Assessment of this association in juvenile idiopathic arthritis (JIA) is complicated by age-dependent IgG glycan variation. The aim of this study was to conduct the first large-scale survey of IgG glycans in healthy children and patients with JIA, with a focus on early childhood, the time of peak JIA incidence.