CURRENT BIOINFORMATICS, cilt.12, ss.320-328, 2017 (SCI İndekslerine Giren Dergi)
Background: A group of interconnected genes in a protein-protein interaction network that contains most of the disease associated genes is called an active subnetwork. Active subnetwork search is an NP-hard problem. In the last decade, simulated annealing, greedy search, color coding, genetic algorithm, and mathematical programming based methods are proposed for this problem.