Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells


GOKTAS S., Baran Y. , URAL A. U. , YAZICI S., AYDUR E., BASAL S., et al.

UROLOGY, cilt.75, ss.793-798, 2010 (SCI İndekslerine Giren Dergi)

Özet

OBJECTIVES To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in cell cycle, proliferation, apoptosis, angiogenesis, and cellular resistance to chemotherapy and radiotherapy.